Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse
نویسندگان
چکیده
منابع مشابه
Strain Background Modifies Phenotypes in the ATP8B1-Deficient Mouse
BACKGROUND Mutations in ATP8B1 (FIC1) underlie cases of cholestatic disease, ranging from chronic and progressive (progressive familial intrahepatic cholestasis) to intermittent (benign recurrent intrahepatic cholestasis). The ATP8B1-deficient mouse serves as an animal model of human ATP8B1 deficiency. METHODOLOGY/PRINCIPAL FINDINGS We investigated the effect of genetic background on phenotyp...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0008984